Cajun Chicken Alfredo

Featured in: Unhurried Dinner Ideas

This vibrant dish marries Southern Cajun spices with classic Italian Alfredo for a memorable meal. Cajun-seasoned chicken breasts are seared until golden, then combined with a homemade cream sauce enriched with Parmesan cheese and fragrant garlic. The creamy sauce clings beautifully to fettuccine pasta, creating layers of flavor and texture.

Preparation takes just 40 minutes total, making it ideal for weeknight dinners. The key to success is cooking the chicken until golden and juicy while simmering the cream sauce gently to achieve the perfect silky consistency. Fresh parsley and extra Parmesan finish the dish with brightness and richness.

Updated on Sun, 18 Jan 2026 14:09:00 GMT
Sliced Cajun chicken breast rests atop creamy fettuccine Alfredo, garnished with fresh parsley and extra Parmesan, ready to serve. Save to Pinterest
Sliced Cajun chicken breast rests atop creamy fettuccine Alfredo, garnished with fresh parsley and extra Parmesan, ready to serve. | lentomeals.com

My neighbor once knocked on my door holding a takeout container, insisting I try what she called "the best pasta disaster" she'd ever made. It was Cajun Chicken Alfredo, born from a power outage that forced her to improvise with what she had. The heat from the Cajun spices cut through the cream in a way I didn't expect, and I stood there in my doorway, fork in hand, completely hooked. That spontaneous taste became my weekend project for the next month.

I made this for a group of friends who claimed they didn't like spicy food, and watched them go back for seconds anyway. One of them scraped the bottom of the skillet with a piece of bread, which I took as the highest compliment. The combination of creamy and spicy seemed to override every reservation they had, and the room got quieter as everyone just ate.

Ingredients

  • Boneless, skinless chicken breasts: Pat them completely dry before seasoning or the Cajun spices will clump and slide off instead of forming that beautiful crust.
  • Cajun seasoning: Store-bought works great, but check the salt level first because some blends are heavily salted and you'll need to adjust the sauce accordingly.
  • Fettuccine or linguine: The wide, flat noodles hold onto the creamy sauce better than thin pasta, creating a more satisfying bite every time.
  • Heavy cream: Don't try to lighten this with half-and-half; the sauce won't thicken properly and you'll end up with a watery disappointment.
  • Freshly grated Parmesan: Pre-grated cheese contains anti-caking agents that prevent it from melting smoothly, leaving you with a grainy sauce instead of silky perfection.
  • Garlic: Mince it finely so it melts into the butter without burning, which can happen fast and turn the whole sauce bitter.
  • Red pepper flakes: Optional, but they add a secondary layer of heat that lingers pleasantly after the Cajun spice fades.
  • Fresh parsley: It's not just for looks; the herbaceous brightness cuts through the richness and makes the dish feel more balanced.

Instructions

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Cook the pasta:
Boil salted water and cook the fettuccine until it still has a slight bite, then save half a cup of that starchy water before draining. That pasta water is your secret weapon for adjusting sauce consistency later.
Season and cook the chicken:
Rub the dried chicken breasts with Cajun seasoning, pressing it into the surface, then sear them in hot olive oil until golden and cooked through, about 5 to 6 minutes per side. Let them rest before slicing so the juices don't run out onto your cutting board.
Build the Alfredo base:
Melt butter in the same skillet, add the garlic, and let it sizzle for just 30 seconds until fragrant. Pour in the heavy cream and whisk constantly as it heats to a gentle simmer, never letting it boil or it may break.
Thicken the sauce:
Stir in the Parmesan, black pepper, salt, and optional red pepper flakes, then let it simmer for 2 to 3 minutes until it coats the back of a spoon. If it gets too thick, add reserved pasta water a tablespoon at a time until it's silky.
Toss and serve:
Add the cooked pasta to the skillet and toss until every strand is coated, then add the sliced Cajun chicken and toss again. Serve immediately with chopped parsley and extra Parmesan on top.
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A skillet of sizzling Cajun chicken Alfredo pasta showcases the rich, creamy sauce clinging to each strand of fettuccine. Save to Pinterest
A skillet of sizzling Cajun chicken Alfredo pasta showcases the rich, creamy sauce clinging to each strand of fettuccine. | lentomeals.com

There was a rainy evening when I made this alone, no guests or plans, just me and a skillet. I ate it straight from the pan with a fork, standing by the stove, and realized that sometimes the best meals are the ones you don't have to share. The warmth of the spices and the comfort of the cream felt like exactly what that quiet night needed.

Adjusting the Heat Level

If you're cooking for people with different spice tolerances, season half the chicken with less Cajun spice and keep it separate. You can always add more heat to individual servings with extra red pepper flakes or hot sauce at the table. I learned this after watching a friend push their plate away because it was too spicy, and I felt terrible for not thinking ahead.

Making It Your Own

Sautéed bell peppers and onions add a sweet crunch that balances the spice, and spinach wilts beautifully into the sauce if you want something green. I've also swapped the chicken for shrimp, which cooks faster and soaks up the Cajun seasoning like a sponge. One time I added sun-dried tomatoes and it became a whole new dish, tangy and rich in ways I didn't expect.

Storing and Reheating

Leftovers keep in the fridge for up to three days in an airtight container, and they reheat gently on the stovetop with a splash of milk or cream to bring the sauce back to life. Don't microwave it on high or the cream will separate and turn oily, which ruins the whole texture. I usually add a pinch of fresh Parmesan and parsley when reheating to make it taste freshly made.

  • Store the chicken and pasta together so the flavors meld overnight.
  • Reheat slowly over low heat, stirring frequently to prevent sticking.
  • Add a little pasta water if the sauce has thickened too much in the fridge.
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Close-up view of golden-brown Cajun chicken strips mixed into creamy Alfredo pasta, highlighting the aromatic herbs and melted cheese. Save to Pinterest
Close-up view of golden-brown Cajun chicken strips mixed into creamy Alfredo pasta, highlighting the aromatic herbs and melted cheese. | lentomeals.com

This dish has a way of turning an ordinary dinner into something people remember, and it doesn't ask for much in return. Keep it in your rotation and you'll always have an answer when someone asks what's for dinner.

Recipe FAQs

How do I prevent the Alfredo sauce from breaking?

Keep the heat at medium and avoid boiling the cream. Whisk constantly when adding cream to the butter and garlic, and stir gently while the cheese melts. If the sauce appears too thick, thin it with reserved pasta water one tablespoon at a time rather than adding more cream.

Can I use chicken thighs instead of breasts?

Yes, chicken thighs work beautifully and stay moister during cooking. They may require an additional 2-3 minutes per side depending on thickness. Ensure they reach an internal temperature of 165°F before slicing.

What's the best way to adjust the spice level?

Control heat by adjusting the amount of Cajun seasoning rubbed on the chicken. Start with less and taste as you go. The optional red pepper flakes in the sauce add extra warmth. You can also reduce or omit them based on preference.

Can I prepare this dish ahead of time?

Cook the chicken and make the sauce in advance, storing them separately in the refrigerator for up to 2 days. Reheat gently before serving. Cook pasta fresh just before combining to maintain its texture and quality.

What vegetables pair well with this dish?

Sautéed bell peppers, spinach, mushrooms, or roasted broccoli complement the creamy sauce beautifully. Add vegetables to the skillet before combining with pasta, cooking them until tender.

Is there a good wine pairing for this dish?

A crisp white wine like Sauvignon Blanc cuts through the richness of the Alfredo sauce while complementing the Cajun spices. Pinot Grigio or Chardonnay also work well as alternatives.

Cajun Chicken Alfredo

Spicy Cajun chicken tossed with silky Alfredo sauce and tender pasta—a bold fusion of Southern heat and Italian comfort.

Prep Time
15 minutes
Cook Time
25 minutes
Time Needed
40 minutes
Created by Rachel Ivey


Skill Level Medium

Cuisine American Cajun-Italian Fusion

Makes 4 Serves

Diet Information None specified

What You'll Need

Chicken

01 2 large boneless, skinless chicken breasts
02 1 tablespoon Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine or linguine pasta

Alfredo Sauce

01 2 tablespoons unsalted butter
02 3 cloves garlic, minced
03 1.5 cups heavy cream
04 1 cup freshly grated Parmesan cheese
05 0.25 teaspoon ground black pepper
06 0.25 teaspoon salt
07 0.25 teaspoon red pepper flakes

Garnish

01 2 tablespoons chopped fresh parsley
02 Extra grated Parmesan for serving

Steps

Step 01

Cook pasta to al dente: Bring a large pot of salted water to a boil. Add fettuccine and cook according to package directions until al dente. Reserve 0.5 cup pasta water and drain remaining pasta. Set aside.

Step 02

Season and prepare chicken: Pat chicken breasts dry with paper towels and rub evenly on both sides with Cajun seasoning.

Step 03

Sear chicken until golden: Heat olive oil in a large skillet over medium-high heat. Add seasoned chicken breasts and cook for 5-6 minutes per side until golden brown and internal temperature reaches 165°F. Remove from skillet, rest for 2-3 minutes, then slice into strips.

Step 04

Create Alfredo sauce base: In the same skillet over medium heat, melt butter. Add minced garlic and sauté for 30 seconds until fragrant. Pour in heavy cream while whisking constantly and bring to a gentle simmer without boiling.

Step 05

Finish sauce with cheese and seasonings: Stir in Parmesan cheese, black pepper, salt, and red pepper flakes. Simmer for 2-3 minutes until sauce thickens. Add reserved pasta water one tablespoon at a time if sauce becomes too thick.

Step 06

Combine pasta, sauce, and chicken: Add cooked pasta to the skillet and toss thoroughly to coat with Alfredo sauce. Add sliced Cajun chicken and toss again until fully incorporated.

Step 07

Plate and serve: Transfer to serving dishes immediately. Garnish with chopped fresh parsley and additional grated Parmesan cheese.

Kitchen Tools

  • Large pot
  • Large skillet
  • Tongs
  • Chef's knife
  • Cutting board
  • Measuring cups and spoons
  • Whisk

Allergy Info

Always review every ingredient for potential allergens. Talk to your healthcare provider if you have any concerns.
  • Contains milk: heavy cream, unsalted butter, Parmesan cheese
  • Contains wheat: pasta
  • May contain eggs if using fresh pasta varieties
  • Verify Cajun seasoning ingredients for gluten and other potential allergens

Nutrition Details (per portion)

These numbers are for your information only. Always check with a health professional for dietary guidance.
  • Calories: 670
  • Total fat: 34 g
  • Carbohydrates: 54 g
  • Proteins: 40 g